FREE
Limited Offer
Free Bacteriostatic
Water (10ml)
Enter your email. We send the code. You pay postage. That’s it.
No spam. Unsubscribe any time.
VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide produced throughout the nervous system and GI tract, acting as both a neurotransmitter and hormone across gut motility, immune regulation, and circadian pacemaking. Its synthetic analogue, Aviptadil, received FDA Breakthrough Therapy Designation for COVID-19-associated respiratory failure. In rheumatoid arthritis research, VIP reduced synovial inflammation and joint damage scores; in a PAH Phase II trial, it significantly reduced mean pulmonary arterial pressure.
For in vitro laboratory research use only. Not for human consumption. All findings described are from preclinical or in vitro models.
In vitro and preclinical mechanistic observations
Potently inhibits macrophage and dendritic cell production of TNF-α, IL-6, IL-12, and nitric oxide — reducing pro-inflammatory cytokine storms via G-protein coupled receptor signalling.
Promotes Treg differentiation and function — the key mechanism behind its anti-autoimmune properties in rheumatoid arthritis and other Th1-mediated inflammatory conditions.
VIP produced by the suprachiasmatic nucleus synchronises cellular clocks throughout the body — essential for normal circadian pacemaking and downstream hormonal rhythms.
Potent pulmonary vasodilator with clinical relevance in pulmonary arterial hypertension — Phase II data showed significant reduction in mean pulmonary arterial pressure.
Quantitative findings from published preclinical research
Source: Delgado et al. (2004) J Immunol. PMID 15280416. In vitro / preclinical inflammatory models.
Observed tolerability data from in vitro and animal model research
Tolerability
Low SeverityTransient Flushing
Low SeverityHypotension (IV)
Medium SeveritySafety data reflects preclinical observations only. Human clinical safety profiles may differ substantially. For in vitro laboratory research use only. Not for human consumption.
Primary literature — links open PubMed or original journal source
Syntra Compound Library
View VIP specifications, batch data, and Certificate of Analysis in the Syntra research compound catalogue.
View VIP in the Syntra Compound Library →For in vitro laboratory research use only. Not for human consumption.
Enter your email. We send the code. You pay postage. That’s it.
No spam. Unsubscribe any time.