FREE
Limited Offer
Free Bacteriostatic
Water (10ml)
Enter your email. We send the code. You pay postage. That’s it.
No spam. Unsubscribe any time.
Semax is a synthetic heptapeptide analogue of ACTH(4-10) developed at the Institute of Molecular Genetics in Russia and approved for clinical use since 1991 for stroke treatment and cognitive impairment. Dolotov et al. demonstrated that a single intranasal dose produced 8-fold increases in BDNF protein in the hippocampus within 24 hours, persisting for 72 hours — positioning Semax as the most potent BDNF-elevating peptide studied to date in preclinical models.
For in vitro laboratory research use only. Not for human consumption. All findings described are from preclinical or in vitro models.
In vitro and preclinical mechanistic observations
A single intranasal dose produces 8-fold hippocampal BDNF increases within 24 hours — the most potent BDNF-elevating effect documented for any single peptide in preclinical models.
Also increases Nerve Growth Factor and VEGF — promoting neuronal survival, new synapse formation, and vascular repair in the CNS.
Activates Hypoxia-Inducible Factor-1α under ischaemic conditions, protecting neurons from oxygen deprivation — the mechanism behind its stroke recovery data.
Enhances dopaminergic neurotransmission in the mesocortical pathway, contributing to pro-cognitive and focus-enhancing effects observed in both animal and human research.
Quantitative findings from published preclinical research
BDNF relative to baseline (fold-change). Source: Dolotov et al. (2006) J Neurochem. PMID 16899067. Rat hippocampus model.
Observed tolerability data from in vitro and animal model research
Tolerability
Low SeverityMild Nasal Irritation
Low SeverityTransient Headache
Low SeveritySafety data reflects preclinical observations only. Human clinical safety profiles may differ substantially. For in vitro laboratory research use only. Not for human consumption.
Primary literature — links open PubMed or original journal source
Syntra Compound Library
View SEMAX specifications, batch data, and Certificate of Analysis in the Syntra research compound catalogue.
View SEMAX in the Syntra Compound Library →For in vitro laboratory research use only. Not for human consumption.
Enter your email. We send the code. You pay postage. That’s it.
No spam. Unsubscribe any time.