FOR RESEARCH USE ONLY — All compounds sold for in vitro laboratory research  •  99%+ PURITY GUARANTEED  •  THIRD-PARTY HPLC & MASS SPECTROMETRY VERIFIED  •  COLD-CHAIN OPTIMISED SHIPPING  • 
Home / Compound Library / MOTS-c
COA ↓
Product
COA Doc
SYN-2625
99.0% Purity SYN-2625 Research Grade HPLC Verified

MOTS-c

Mitochondrial ORF Peptide · Research Grade

Select Strength — 10mg

$95.00
C₇₉H₁₄₀N₂₆O₂₅S MW: 2174.18 g/mol CAS: 1627580-64-6
Out of Stock

Notify me when back in stock

For in vitro laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.

Certificate of Analysis

BATCH VERIFICATION

Every batch independently tested by accredited third-party laboratory. Full COA available on request.

Current Batch
HPLC Purity
Lot Number SYN-2625-MOTSC
Test Date
Labeled 98.2%
Actual 98.2%
HPLC Purity
Lot Number SYN-2524-MOTSC
Test Date
Labeled 98.2%
Actual 98.5%

Research Data

KEY FINDINGS

🧬
AMPK
Exercise-Mimetic Activation
Activates AMPK to replicate the metabolic benefits of aerobic exercise
🔬
mtDNA
Mitochondrial DNA Encoded
Discovered at USC 2015 — encoded in the 12S rRNA gene of mtDNA
✅
98.2%
HPLC-Verified Purity
Current batch SYN-2625, third-party accredited lab
❄️
24mo
Lyophilised Shelf Life
At −20°C sealed under inert atmosphere

Mechanisms of Action

IN VITRO RESEARCH OVERVIEW

Data presented from peer-reviewed in vitro studies. All findings are laboratory observations only.

⚡ Exercise Mimetic

MOTS-c Discovery — Mitochondrial Hormone Activates AMPK

Lee et al. discovered MOTS-c in 2015 and demonstrated it activates AMPK via AICAR accumulation, replicating the intracellular metabolic signature of aerobic exercise. In high-fat diet mouse models, MOTS-c fully reversed insulin resistance and prevented obesity progression.

Insulin sensitivity (MOTS-c) Normalised
Body weight (MOTS-c + HFD) −15%
HFD control −62% sensitivity
🔬 Complete reversal of HFD-induced insulin resistance — MOTS-c is the only mitochondria-encoded peptide demonstrating systemic exercise-mimetic activity.
PMID 25738459 — Cell Metabolism
100 %
Complete Reversal of High-Fat Diet Insulin Resistance

MOTS-c activates AMPK by inhibiting the AICAR-transformylase step of the folate cycle — mimicking the intracellular energy deficit signal of exercise. In multiple animal models, MOTS-c fully reversed high-fat diet-induced obesity and insulin resistance, with enhanced longevity markers in centenarian genetic studies.

Insulin Sensitivity — MOTS-c vs. HFD Control
Insulin sensitivity (MOTS-c + HFD) Normalised
Insulin sensitivity (HFD control) −62%
Body weight gain (MOTS-c + HFD) −15%
Source: Lee C et al., Cell Metabolism, 2015

Analytical Data

PURITY VERIFICATION

Purity by Method — Batch SYN-2625-MOTSC
Specification Value
CAS Number 1627580-64-6
Molecular Formula C₇₉H₁₄₀N₂₆O₂₅S
Molecular Weight 2174.18 g/mol
Purity (HPLC) 99.0%
Appearance White lyophilised powder
Solubility Soluble in water (1 mg/mL)
Storage −20°C long-term / 2–8°C short-term
Shelf Life 24 months from production date
Research Grade Yes — For In Vitro Use Only
📊

What Research Has Shown

TRIAL RESULTS

MOTS-c Discovery Study — Cell Metabolism, 2015

100 %

Insulin Resistance Reversal in High-Fat Diet Animal Model

MOTS-c (HFD model) Normalised
HFD control (untreated) −62% sensitivity

Comparative Activity Profile

MOTS-c
🛡️

In Vitro Safety Data

SAFETY PROFILE

MOTS-c is an endogenous mitochondria-encoded peptide present in human circulation — not a synthetic xenobiotic. It has been associated with extreme longevity in genetic studies (centenarian enrichment). Preclinical and early research datasets show a favourable safety profile consistent with an endogenous regulatory peptide.

Observed Adverse Indicators

5%

Transient injection-site reaction

low
2%

Mild fatigue post-administration

low
0%

Serious adverse events reported

low

⚠️ Theoretical Concern

Endogenous Origin & Research Safety Context

MOTS-c is encoded in the 12S rRNA gene of mitochondrial DNA and circulates endogenously. Its safety profile is supported by both preclinical data and genetic longevity association studies.

  • Endogenous mtDNA-encoded peptide — present in human blood; not a novel xenobiotic compound
  • Gene variants enriched in Japanese centenarians — genetic evidence for longevity association without toxicity
  • Tissue-specific AMPK activation in muscle, adipose, and liver — metabolic effect localised to relevant tissues
  • For in vitro laboratory research use only — not for human or veterinary administration
❓

Researcher Reference

FREQUENTLY ASKED QUESTIONS

Peer-Reviewed Literature

RESEARCH CITATIONS

Cell Metabolism
A Mitochondrial Peptide MOTS-c Regulates Insulin Sensitivity via AMPK
2015 Lee C et al.
PMID 25738459 — View on PubMed

All citations refer to published peer-reviewed in vitro research. Data presented for scientific reference only. No claims made regarding human therapeutic use.

$95.00
Spend $100.00 more for free shipping
$0 Free at $100
Top Compounds →