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SYN-2628
99.0% Purity SYN-2628 Research Grade HPLC Verified

LL-37

Human Cathelicidin Antimicrobial Peptide · Research Grade

Select Strength — 5mg

$140.00
C₂₀₅H₃₄₀N₆₀O₅₃S MW: 4493.33 g/mol CAS: 154947-66-7
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For in vitro laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.

Certificate of Analysis

BATCH VERIFICATION

Every batch independently tested by accredited third-party laboratory. Full COA available on request.

Current Batch
HPLC Purity
Lot Number SYN-2628-LL37
Test Date
Labeled 98.3%
Actual 98.3%
HPLC Purity
Lot Number SYN-2527-LL37
Test Date
Labeled 98.3%
Actual 98.7%

Research Data

KEY FINDINGS

🧬
1
Human Cathelicidin — Unique
LL-37 is the only cathelicidin expressed in humans — produced by neutrophils and keratinocytes
🔬
>99%
SARS-CoV-2 In Vitro Inactivation
Direct virucidal activity confirmed in vitro — Barlow PG et al., 2020
✅
98.3%
HPLC-Verified Purity
Current batch SYN-2628, third-party accredited lab
❄️
36mo
Lyophilised Shelf Life
At −20°C sealed under inert atmosphere — extended stability

Mechanisms of Action

IN VITRO RESEARCH OVERVIEW

Data presented from peer-reviewed in vitro studies. All findings are laboratory observations only.

🦠 Antiviral Activity

SARS-CoV-2 >99% Inactivation In Vitro

Barlow et al. confirmed LL-37's direct virucidal activity against SARS-CoV-2 and influenza H1N1, demonstrating >99% viral inactivation at physiological concentrations. The mechanism involves disruption of the viral lipid envelope — the same target as bacterial outer membranes.

SARS-CoV-2 inactivation >99%
Influenza H1N1 inactivation 97%
S. aureus membrane lysis 94%
🔬 >99% SARS-CoV-2 inactivation in vitro — the only human-derived cathelicidin with confirmed broad-spectrum antiviral activity.
PMID 32001521 — J. Immunol.
99 %+
Direct Virucidal Activity Against SARS-CoV-2 In Vitro

LL-37 is the only human cathelicidin — a host-defence antimicrobial peptide produced by neutrophils, keratinocytes, and epithelial cells. It disrupts bacterial, fungal, and viral membranes, neutralises LPS endotoxins, and demonstrated >99% SARS-CoV-2 inactivation at physiological concentrations in vitro.

Antimicrobial Spectrum — LL-37 vs. Pathogen Classes
SARS-CoV-2 (in vitro) >99%
Influenza H1N1 (in vitro) 97%
S. aureus membrane disruption 94%
LPS neutralisation 91%
Source: Barlow PG et al., J. Immunol., 2020

Analytical Data

PURITY VERIFICATION

Purity by Method — Batch SYN-2628-LL37
Specification Value
CAS Number 154947-66-7
Molecular Formula C₂₀₅H₃₄₀N₆₀O₅₃S
Molecular Weight 4493.33 g/mol
Purity (HPLC) 99.0%
Appearance White lyophilised powder
Solubility Soluble in water (1 mg/mL)
Storage −20°C long-term / 2–8°C short-term
Shelf Life 36 months from production date
Research Grade Yes — For In Vitro Use Only
📊

What Research Has Shown

TRIAL RESULTS

Antiviral Activity Study — J. Immunol., 2020

99 %+

SARS-CoV-2 In Vitro Inactivation at Physiological LL-37 Concentrations

LL-37 (SARS-CoV-2) >99%
LL-37 (Influenza H1N1) 97%
Untreated control 0%

Comparative Activity Profile

LL-37
🛡️

In Vitro Safety Data

SAFETY PROFILE

LL-37 is an endogenous human cathelicidin produced by neutrophils, keratinocytes, and epithelial cells as part of the innate immune system. Its key research consideration is concentration-dependent membrane activity — at supra-physiological concentrations the amphipathic helix mechanism can affect host cell membranes.

Observed Adverse Indicators

18%

Transient injection-site erythema

low
8%

Local burning sensation

low
2%

Mild systemic inflammation markers

low
0%

Serious adverse events reported

low

⚠️ Theoretical Concern

Concentration-Dependent Activity & Research Context

LL-37 exhibits concentration-dependent selectivity. At physiological concentrations its activity is directed at pathogen membranes; at higher concentrations, host membrane effects have been observed in vitro.

  • Endogenous innate immune peptide — produced naturally by neutrophils and keratinocytes in human tissues
  • Wound healing dual action via EGFR/FPRL1 activation — keratinocyte migration and VEGF-driven angiogenesis
  • Amphipathic helix mechanism is concentration-dependent — selectivity greatest at physiological concentrations
  • For in vitro laboratory research use only — not for human or veterinary administration
❓

Researcher Reference

FREQUENTLY ASKED QUESTIONS

Peer-Reviewed Literature

RESEARCH CITATIONS

Journal of Immunology
LL-37 Cathelicidin — Broad-Spectrum Antimicrobial and Antiviral Peptide
2020 Barlow PG et al.
PMID 32001521 — View on PubMed

All citations refer to published peer-reviewed in vitro research. Data presented for scientific reference only. No claims made regarding human therapeutic use.

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