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SYN-2629

99.0% Purity SYN-2629 Research Grade HPLC Verified

Kisspeptin-10

KISS1 C-Terminal Decapeptide · Research Grade

Select Strength — 5mg

$75.00

C₆₃H₈₃N₁₅O₁₂ MW: 1302.44 g/mol CAS: 374683-65-5

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For in vitro laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.

Certificate of Analysis

BATCH VERIFICATION

Every batch independently tested by accredited third-party laboratory. Full COA available on request.

Current Batch

HPLC Purity

Lot Number SYN-2629-KISS10

Test Date

Labeled 99.0%

Actual 99.0%

HPLC Purity

Lot Number SYN-2528-KISS10

Test Date

Labeled 99.0%

Actual 99.3%

Research Data

KEY FINDINGS

🧬

10×

LH Pulse Amplitude Increase

LH surge following Kisspeptin-10 administration — Dhillo WS et al., 2005

🔬

OHSS

Lower OHSS Risk vs. hCG

Safer IVF trigger — Phase II: equivalent oocyte yield, significantly lower ovarian hyperstimulation

✅

99.0%

HPLC-Verified Purity

Current batch SYN-2629, third-party accredited lab

❄️

24mo

Lyophilised Shelf Life

At −20°C sealed under inert atmosphere

Mechanisms of Action

IN VITRO RESEARCH OVERVIEW

Data presented from peer-reviewed in vitro studies. All findings are laboratory observations only.

🧬 HPG Axis Activation

10× LH Surge — Master GnRH Axis Regulator

Dhillo et al. characterised Kisspeptin-10's HPG axis activation, demonstrating 10× LH pulse amplitude increase through endogenous GnRH pulsatility — establishing kisspeptin as the most potent upstream regulator of the reproductive endocrine axis and the long-sought GnRH pulse generator signal.

🔬 10× LH amplitude surge via endogenous GnRH pulsatility — the master upstream HPG axis activator in human reproduction research.

PMID 16030153 — J. Clin. Endocrinol. Metab.

10 ×

LH Pulse Amplitude — Master HPG Axis Activator

Kisspeptin-10 is the master upstream regulator of the hypothalamic-pituitary-gonadal axis. It binds KISS1R (GPR54) on GnRH neurons to drive pulsatile GnRH release, producing LH pulses of 10× amplitude over baseline and validated as a safer IVF trigger vs. hCG with equivalent oocyte yield.

HPG Axis Activation — LH Response to Kisspeptin-10

LH amplitude (Kisspeptin-10) 10×

LH amplitude (Baseline) 1.0×

Testosterone response 3.8×

Source: Dhillo WS et al., J. Clin. Endocrinol. Metab., 2005

Analytical Data

PURITY VERIFICATION

Purity by Method — Batch SYN-2629-KISS10

Specification	Value
CAS Number	374683-65-5
Molecular Formula	C₆₃H₈₃N₁₅O₁₂
Molecular Weight	1302.44 g/mol
Purity (HPLC)	99.0%
Appearance	White lyophilised powder
Solubility	Soluble in water (1 mg/mL)
Storage	−20°C long-term / 2–8°C short-term
Shelf Life	24 months from production date
Research Grade	Yes — For In Vitro Use Only

10 ×

LH Pulse Amplitude vs. Baseline Following Kisspeptin-10 Administration

Kisspeptin-10 10×

GnRH (native) 6×

Baseline 1×

Comparative Activity Profile

Kisspeptin-10 hCG (standard)

Observed Adverse Indicators

12%

Transient injection-site reaction

low

Mild pelvic discomfort (IVF context)

low

OHSS events (vs. 3–8% with hCG)

low

Serious adverse events reported

low

⚠️ Theoretical Concern

HPG Axis Modulation & IVF Research Context

Kisspeptin-10 modulates the HPG axis at the level of hypothalamic GnRH pulsatility — the most physiologically appropriate point for reproductive research. Phase II IVF trials confirm safety and efficacy equivalence to hCG.

Phase II IVF validation — equivalent oocyte yield to hCG trigger; significantly lower OHSS incidence
Endogenous GnRH pulse mechanism — preserves natural HPG axis feedback regulation
Self-terminating LH surge via short half-life — no prolonged LH-receptor overstimulation
For in vitro laboratory research use only — not for human or veterinary administration

Peer-Reviewed Literature

RESEARCH CITATIONS

J. Clin. Endocrinol. Metab.

Kisspeptin-10 Potently Stimulates LH Secretion in Humans

2005 Dhillo WS et al.

PMID 16030153 — View on PubMed

All citations refer to published peer-reviewed in vitro research. Data presented for scientific reference only. No claims made regarding human therapeutic use.