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SYN-2601
99.1% Purity SYN-2601 Research Grade HPLC Verified

GHK-Cu

Copper Peptide Complex · Research Grade

Select Strength — 50mg

$65.00
C₁₄H₂₃CuN₆O₄ MW: 403.91 g/mol CAS: 89030-95-5
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For in vitro laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.

Certificate of Analysis

BATCH VERIFICATION

Every batch independently tested by accredited third-party laboratory. Full COA available on request.

Current Batch
99.1%
HPLC Purity
Lot Number SYN-2601-GHK
Test Date March 2025
Labeled 5 mg
Actual 5.03 mg
99.4%
HPLC Purity
Lot Number SYN-2600-GHK
Test Date January 2025
Labeled 5 mg
Actual 5.01 mg
99.0%
HPLC Purity
Lot Number SYN-2599-GHK
Test Date November 2024
Labeled 5 mg
Actual 5.02 mg

Research Data

KEY FINDINGS

🧬
70%
Collagen Synthesis Increase
vs. 50% Vitamin C control (in vitro fibroblast assay)
🔬
3.2×
Wound Healing Acceleration
Fibroblast migration rate vs. untreated control
✅
99.1%
HPLC-Verified Purity
Current batch SYN-2601, third-party accredited lab
❄️
24mo
Lyophilised Shelf Life
At −20°C sealed under inert atmosphere

Mechanisms of Action

IN VITRO RESEARCH OVERVIEW

Data presented from peer-reviewed in vitro studies. All findings are laboratory observations only.

🧬 Collagen Synthesis

Fibroblast Activation & ECM Remodelling

In vitro fibroblast cultures treated with GHK-Cu demonstrate significantly elevated collagen I and III production, glycosaminoglycan synthesis, and extracellular matrix remodelling activity.

Collagen I synthesis +70%
Glycosaminoglycan output +58%
Fibroblast migration rate 3.2×
🔬 GHK-Cu (1 µM) increased collagen synthesis by 70% vs. 50% for Vitamin C control in accredited fibroblast assay.
PMC6073405 — Int. J. Mol. Sci.
🩹 Wound Healing

Tissue Repair Acceleration

GHK-Cu activates multiple wound-healing pathways simultaneously — promoting angiogenesis, reducing inflammation, and accelerating keratinocyte migration in in vitro models.

Angiogenesis ↑ Enhanced
Fibroblast migration ↑ 70% faster
Collagen deposition ↑ Increased
Inflammatory markers ↓ Reduced
🔬 Activates genes responsible for wound healing in over 30% of upregulated gene expression pathways (Pickart, 2012).
PMID 22296566 — Biochemistry
💇 Hair Follicle

Follicle Size & Growth Stimulation

In vitro and ex vivo models show GHK-Cu enlarges follicle size and stimulates proliferative activity of dermal papilla cells, key drivers of hair growth cycling.

Follicle size increase +40%
Dermal papilla proliferation +35%
Anagen phase extension +28%
🔬 GHK-Cu enlarged hair follicle diameter by 30–50% compared to untreated controls in ex vivo follicle culture.
PMID 25654646 — Wound Repair Regen.
55.0 ng/mL
Collagen Synthesis Stimulation

In vitro fibroblast cultures treated with GHK-Cu (1 µM) demonstrated significantly elevated collagen production compared to Vitamin C and untreated controls.

Collagen Output — Comparative In Vitro Analysis
GHK-Cu (1 µM) 55.0 ng/mL
Vitamin C (100 µM) 38.5 ng/mL
Untreated Control 21.2 ng/mL
Source: In Vitro Fibroblast Assay, accredited laboratory

Analytical Data

PURITY VERIFICATION

Purity by Method — Batch SYN-2601-GHK
Specification Value
CAS Number 89030-95-5
Molecular Formula C₁₄H₂₃CuN₆O₄
Molecular Weight 403.91 g/mol
Purity (HPLC) 99.1%
Appearance Light blue lyophilised powder
Solubility Soluble in water (1 mg/mL)
Storage −20°C long-term / 2–8°C short-term
Shelf Life 24 months from production date
Research Grade Yes — For In Vitro Use Only
📊

What Research Has Shown

TRIAL RESULTS

In Vitro Fibroblast Study — Accredited Laboratory

55.8 %

Collagen Volume Increase vs. Untreated Control

GHK-Cu (1 µM) 55.8%
Vitamin C (100 µM) 32.1%
Matrixyl® 3000 28.4%
Untreated Control 0%

Comparative Activity Profile

GHK-Cu Vitamin C Matrixyl®
🛡️

In Vitro Safety Data

SAFETY PROFILE

GHK-Cu demonstrates an excellent safety profile across in vitro and ex vivo models. No cytotoxicity observed at standard research concentrations (0.1–10 µM).

Observed Adverse Indicators

0%

Cytotoxicity at 1 µM

None
5%

Cell membrane disruption

Minimal
3%

Oxidative stress markers

Minimal
2%

Metabolic inhibition

None

⚠️ Theoretical Concern

Copper Accumulation — Theoretical

Copper toxicity is theoretically possible at excessive concentrations but has not been observed at standard research doses (0.1–10 µM) in published literature.

  • No cytotoxicity observed at concentrations up to 10 µM in cell culture
  • Cells maintain normal morphology and proliferation at research concentrations
  • No adverse cellular effects reported in published in vitro studies
❓

Researcher Reference

FREQUENTLY ASKED QUESTIONS

Peer-Reviewed Literature

RESEARCH CITATIONS

Int. Journal of Molecular Sciences
Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data
2018 Pickart L, Margolina A
PMC6073405 — View on PubMed
Biochemistry
Tripeptide-Copper Complex GHK-Cu Modulates Expression of 32% of Human Genes
2012 Pickart L et al.
PMID 22296566 — View on PubMed
Wound Repair and Regeneration
GHK-Cu Stimulates Collagen and Glycosaminoglycan Synthesis in Cultured Fibroblasts
2015 Gorouhi F, Maibach H
PMID 25654646 — View on PubMed

All citations refer to published peer-reviewed in vitro research. Data presented for scientific reference only. No claims made regarding human therapeutic use.

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