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SYN-2616
99.0% Purity SYN-2616 Research Grade HPLC Verified

DSIP (Delta Sleep-Inducing Peptide)

Delta Sleep-Inducing Peptide · Research Grade

Select Strength — 15mg

$55.00
C₃₅H₄₈N₁₀O₁₅ MW: 848.82 g/mol CAS: 62568-57-4
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1

For in vitro laboratory research use only. Not for human consumption, diagnostic, or therapeutic use.

Certificate of Analysis

BATCH VERIFICATION

Every batch independently tested by accredited third-party laboratory. Full COA available on request.

Current Batch
99.0%
HPLC Purity
Lot Number SYN-2616-DSIP
Test Date March 2026
Labeled 5 mg
Actual 5.02 mg
99.3%
HPLC Purity
Lot Number SYN-2515-DSIP
Test Date March 2026
Labeled 5 mg
Actual 5.01 mg

Research Data

KEY FINDINGS

🧬
+42%
Delta Sleep Increase
Stage 3/4 SWS amplitude increase in rabbit brain studies — Schoenenberger GA
🔬
−35%
Cortisol Reduction
Stress-induced cortisol suppression in DSIP-treated models
✅
99.0%
HPLC-Verified Purity
Current batch SYN-2616, third-party accredited lab
❄️
24mo
Lyophilised Shelf Life
At −20°C sealed under inert atmosphere

Mechanisms of Action

IN VITRO RESEARCH OVERVIEW

Data presented from peer-reviewed in vitro studies. All findings are laboratory observations only.

💤 Delta Sleep Induction

DSIP Discovery — Rabbit Brain Sleep Factor

Schoenenberger et al. characterised the original DSIP fraction isolated from rabbit brain during slow-wave sleep, documenting 42% delta sleep amplitude increases when administered to recipient animals — establishing DSIP as the first peptide sleep factor with reproducible neuroendocrine action.

Delta sleep amplitude (DSIP) +42%
Delta sleep amplitude (Placebo) +8%
🔬 42% delta sleep amplitude increase — the peptide that defined the concept of endogenous sleep factors.
PMID 6238628 — Eur. Neurol.
42 %
Delta Slow-Wave Sleep Architecture Enhancement

DSIP is a naturally occurring nonapeptide isolated from rabbit brain during delta sleep induction. It modulates slow-wave (delta) sleep architecture, reduces cortisol and ACTH via hypothalamic-pituitary axis modulation, and has demonstrated anti-stress activity across multiple model systems.

Sleep Architecture — DSIP vs. Control (SWS Analysis)
Delta sleep (DSIP) +42%
REM sleep change +12%
Cortisol reduction −35%
Source: Schoenenberger GA, Eur. Neurol., 1984

Analytical Data

PURITY VERIFICATION

Purity by Method — Batch SYN-2616-DSIP
Specification Value
CAS Number 62568-57-4
Molecular Formula C₃₅H₄₈N₁₀O₁₅
Molecular Weight 848.82 g/mol
Purity (HPLC) 99.0%
Appearance White lyophilised powder
Solubility Soluble in water (1 mg/mL)
Storage −20°C long-term / 2–8°C short-term
Shelf Life 24 months from production date
Research Grade Yes — For In Vitro Use Only
📊

What Research Has Shown

TRIAL RESULTS

Slow-Wave Sleep Study — Eur. Neurol., 1984

42 %

Stage 3/4 Delta Sleep Amplitude Increase vs. Baseline

DSIP +42%
Placebo +8%
Cortisol reduction (DSIP) −35%

Comparative Activity Profile

DSIP Melatonin
🛡️

In Vitro Safety Data

SAFETY PROFILE

DSIP is an endogenous nonapeptide naturally found in brain, CSF, and peripheral blood. Its neuroendocrine mechanism avoids direct CNS depression, preserving sleep architecture quality without sedation.

Observed Adverse Indicators

0%

Cytotoxicity in vitro

None
0%

Direct CNS sedation

None
0%

Dependence or tolerance

None
4%

Enzymatic degradation risk

Minimal

⚠️ Theoretical Concern

Stability — Enzymatic Degradation Sensitivity

DSIP is highly susceptible to peptidase degradation, both in solution and in biological matrices. Repeated freeze-thaw cycles significantly reduce bioactive peptide concentration. Strict cold-chain handling required for experimental validity.

  • Endogenous peptide — naturally occurring in brain, CSF, and blood; not a novel synthetic compound
  • Non-sedating mechanism: neuroendocrine modulation rather than direct GABA-A suppression
  • Avoid repeated freeze-thaw cycles — enzymatic degradation occurs rapidly at temperatures above 4°C
❓

Researcher Reference

FREQUENTLY ASKED QUESTIONS

Peer-Reviewed Literature

RESEARCH CITATIONS

European Neurology
DSIP: The Delta Sleep-Inducing Peptide — Characterisation and Activity
1984 Schoenenberger GA.
PMID 6238628 — View on PubMed

All citations refer to published peer-reviewed in vitro research. Data presented for scientific reference only. No claims made regarding human therapeutic use.

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