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Epitalon (Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from Epithalamin — a natural polypeptide from the pineal gland. Developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, it is one of the most thoroughly studied longevity peptides, with a 15-year human follow-up study reporting significantly reduced cardiovascular and all-cause mortality. Its primary mechanism involves activation of telomerase (hTERT) — the enzyme that rebuilds telomere length.
For in vitro laboratory research use only. Not for human consumption. All findings described are from preclinical or in vitro models.
In vitro and preclinical mechanistic observations
Directly activates telomerase in human fibroblasts, extending the number of cell divisions beyond the Hayflick limit — the first peptide-mediated demonstration of cellular lifespan extension.
Restores age-related decline in pineal melatonin production, improving circadian rhythm regulation, sleep quality, and systemic antioxidant status.
Acts as a peptide bioregulator — enters cells and binds chromatin to influence expression of genes governing cell cycle regulation, including p53, Bcl-2, and cyclins.
Reduces elevated evening cortisol common in aging, improving HPA axis regulation and stress-response calibration in aged subjects.
Quantitative findings from published preclinical research
Source: Khavinson et al. (2004) Ann NY Acad Sci. PMID 14718457. In vivo Drosophila melanogaster model.
Observed tolerability data from in vitro and animal model research
Tolerability (Human)
Low SeverityInjection-Site Rxn
Low SeverityAdverse Events
Low SeveritySafety data reflects preclinical observations only. Human clinical safety profiles may differ substantially. For in vitro laboratory research use only. Not for human consumption.
Primary literature — links open PubMed or original journal source
Syntra Compound Library
View EPITALON specifications, batch data, and Certificate of Analysis in the Syntra research compound catalogue.
View EPITALON in the Syntra Compound Library →For in vitro laboratory research use only. Not for human consumption.
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