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AOD-9604 (hGH[176–191]) is a synthetic C-terminal fragment of human Growth Hormone with a tyrosine N-terminus addition, developed by Metabolic Pharmaceuticals (Australia) and studied by Professor Norman Baxter at Monash University. It reached Phase IIb/III clinical trials for obesity. Its critical distinction: it replicates GH's lipolytic activity through a beta-3 adrenergic-like pathway while producing no IGF-1 elevation, no insulin resistance, and no anabolic effects — confirmed across multiple human studies.
For in vitro laboratory research use only. Not for human consumption. All findings described are from preclinical or in vitro models.
In vitro and preclinical mechanistic observations
Stimulates lipolysis in fat cells and inhibits lipogenesis through direct receptor interactions — independent of the GH receptor binding that causes full GH's systemic effects.
Operates via a fat-oxidation pathway structurally independent from GH receptor activation, explaining why it lacks GH's diabetogenic, anabolic, and growth-promoting properties.
Confirmed in multiple human studies — no anabolic IGF-1 elevation, eliminating the theoretical cancer-growth concern associated with full GH administration.
Stimulates proteoglycan synthesis in human chondrocytes in vitro and improves histological cartilage scores in rat OA models — an unexpected secondary finding now under investigation.
Quantitative findings from published preclinical research
AOD-9604 values. Source: Heffernan et al. (2001) J Endocrinol; Ng et al. (2000) J Endocrinol.
Observed tolerability data from in vitro and animal model research
Tolerability
Low SeverityInsulin Resistance
Low SeverityInjection-Site Rxn
Low SeveritySafety data reflects preclinical observations only. Human clinical safety profiles may differ substantially. For in vitro laboratory research use only. Not for human consumption.
Primary literature — links open PubMed or original journal source
Syntra Compound Library
View AOD-9604 specifications, batch data, and Certificate of Analysis in the Syntra research compound catalogue.
View AOD-9604 in the Syntra Compound Library →For in vitro laboratory research use only. Not for human consumption.
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